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O tamoxifeno é um modulador seletivo dos receptores de estrogênio amplamente conhecido por sua ação antagonista nos receptores estrogênicos mamários, sendo utilizado clinicamente no tratamento do câncer de mama e, de forma off-label, no manejo da ginecomastia. No entanto, além dessa aplicação principal, o tamoxifeno também exerce um efeito secundário na regulação do eixo hipotálamo-hipófise-testículo , contribuindo para o aumento dos níveis endógenos de testosterona. Esse efeito ocor
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